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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NUMB All Species: 16.06
Human Site: T250 Identified Species: 50.48
UniProt: P49757 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49757 NP_001005743.1 651 70804 T250 T S P T S D A T T S L E M N N
Chimpanzee Pan troglodytes XP_001150743 651 70742 T250 T S P T S D A T T S L E M N N
Rhesus Macaque Macaca mulatta XP_001090008 652 70896 T250 T S P T S D A T T S L E M N N
Dog Lupus familis XP_867854 658 71349 T250 T S P T L D A T A S L E T N N
Cat Felis silvestris
Mouse Mus musculus Q9QZS3 653 70794 T250 T S P T P D G T A S S E M N N
Rat Rattus norvegicus A1L1I3 614 65494 G230 G S F R L S G G G R P A E R E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_990166 582 63254 M202 R E E V M R Q M P D A K A E T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P16554 556 60596 G176 T R R W M C H G F L A C K D S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 99 94.8 N.A. 93.4 49.4 N.A. N.A. 74.5 N.A. N.A. N.A. 36.5 N.A. N.A. N.A.
Protein Similarity: 100 99.6 99.5 96 N.A. 94.9 59.7 N.A. N.A. 79.4 N.A. N.A. N.A. 50 N.A. N.A. N.A.
P-Site Identity: 100 100 100 80 N.A. 73.3 6.6 N.A. N.A. 0 N.A. N.A. N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 80 N.A. 73.3 6.6 N.A. N.A. 6.6 N.A. N.A. N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 50 0 25 0 25 13 13 0 0 % A
% Cys: 0 0 0 0 0 13 0 0 0 0 0 13 0 0 0 % C
% Asp: 0 0 0 0 0 63 0 0 0 13 0 0 0 13 0 % D
% Glu: 0 13 13 0 0 0 0 0 0 0 0 63 13 13 13 % E
% Phe: 0 0 13 0 0 0 0 0 13 0 0 0 0 0 0 % F
% Gly: 13 0 0 0 0 0 25 25 13 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 13 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 13 13 0 0 % K
% Leu: 0 0 0 0 25 0 0 0 0 13 50 0 0 0 0 % L
% Met: 0 0 0 0 25 0 0 13 0 0 0 0 50 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 63 63 % N
% Pro: 0 0 63 0 13 0 0 0 13 0 13 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 13 0 0 0 0 0 0 0 0 % Q
% Arg: 13 13 13 13 0 13 0 0 0 13 0 0 0 13 0 % R
% Ser: 0 75 0 0 38 13 0 0 0 63 13 0 0 0 13 % S
% Thr: 75 0 0 63 0 0 0 63 38 0 0 0 13 0 13 % T
% Val: 0 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _